COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF MELATONIN AND A DERIVATIVE 3-HYDROXYPYRIDINE IN REDUCING OF HEMATOTOXITY COMBINED CHEMORADIATION THERAPY BY MICE WITH LEWIS LUNG CARCINOMA

Siprov Alexander Vladimirovich, Doctor of medical sciences, associate professor, sub-department of pharmacology with a course of clinical pharmacology, Mordovia State University named after N. P. Ogaryov (Saransk), alek_sb@mail.ru
Vashurkina Irina Mikhaylovna, Postgraduate student, Mordovia State University named after N.P.Ogaryov (Saransk), alek_sb@mail.ru

615.27/.28:616.993.192.1:616-092.9

The experiments on mice with Lewis lung carcinoma showed that melaxen and mexidol decreased the injury of the erythrocariocytes blood-forming germ after application of chemoradiotherapy. Melaxen more effectively than mexidol restored erythropoesis and decreased anemia after chemoradiotherapy application. Melaxen and mexidol produced no decrease in the therapeutic efficiency of antitumor therapy.

melaxen, mexidol, hematotoxicity, erythropoesis, chemoradiotherapy.